resources

CLINICAL & SCIENTIFIC

Data

Spartan Medical puts an absolute premium on promoting the best product based on evidence and outcomes. Our advanced medical portfolio is heavily vetted to ensure the ideal treatment pathway is always readily available for our clinical partners and their patients. Below is a list of key published papers and data for review:

WoundCare

Solutions

TheraSkin Meshed Bioactive Split-thickness Skin Allograft

  • Dermagraft data: Marston WA, et al, Dermagraft Diabetic Foot Ulcer Study Group. The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers. Diabetes Care. 2003; 26:1701-1705.
  • Apiligraf Data: Falanga V, Sabolinski ML. A bilayered living skin construct (Apligraf®) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen. 1999.Jul-Aug;7(4):201-7.
  • Landsman, AS; et. al. “Characterization of a Cryopreserved Split-Thickness Human Skin Allograft – TheraSkin” Advances in Skin & Wound Care; Sept. 2016, Vol. 20, No.9; 399-406.
  • Barbul et al., Matched-cohort study comparing bioactive human split-thickness skin allograft plus standard of care to standard of care alone in the treatment of diabetic ulcers: A retrospective analysis across 470 institutions; Wound Repair Regen., 2020 Jan;28(1):81-89. doi: 10.1111/wrr.12767
  • Gutner et al., A retrospective matched-cohort study of 3994 lower extremity wounds of multiple etiologies across 644 institutions comparing a bioactive human skin allograft, TheraSkin, plus standard of care, to standard of care alone

Cygnus Amnion/Chorion & Umbilical Cord Patches

Regenerative Medicine

Solutions

Selphyl Leukocyte Poor PRP

  • Castillo TN, Pouliot MA, Kim HJ, Dragoo JL. Comparison of growth factor and platelet concentration from commercial PRP separation systems. Am J Sports Med. ePub Nov 4, 2010.
  • McCarrel TM., Fortier LA., et. al. Optimization of Leukocyte Concentration in PRP for the Treatment of Tendinopathy. The Journal of Bone & Joint Surgery 2012
  • Braun HJ., Dragoo JL., et. al. The Effect of Platelet-Rich Plasma Formulations and Blood Products on Human Synoviocytes. AJSM 2014
  • Carlos J. Meheux, M.D., Patrick C. McCulloch ET AL., Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review
  • Bobin Mi, Guohuio Liu, Wu Zhou ET AL., Platelet rich plasma versus steroid on lateral epicondylitis: meta-analysis of randomized clinical trials; March 2017; 97-104
  • Kuan-Yu Lin, M.D., Chia-Chi Yang,. et al., Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial; Vol 35, No 1., 2019 pp 106-117

SPARTAN BMA SOLUTIONS

  • Hernigou P, et al Percutaneous Autologous Bone-Marrow Grafting for Nonunions – Influence of the Number and Concentration of Progenitor Cells The Journal of Bone and Joint Volume 87-A No 7 July 2005
  • Muschler GF et al. Spine Fusion Using Cell Matrix Composites Enriched in Bone MarrowDerived Cells; Clinical Ortho.and Related Research; 407, pp. 102–118
  • Hernigou P et al., Biologic augmentation for rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case controlled study; International Orthopaedics: 2014, 38: 1811-1818
  • Murrell WD et al., Regenerative treatments to enhance orthopedic surgical outcomes. American Acad of Phy Med and Rehab 2015; S41-S52
  • Gobbi et al., One-Step Cartilage Repair with Bone Marrow Aspirate Concentrated Cells and Collagen Matrix in Full-Thickness Knee Cartilage Lesions: Results at 2-Year Follow-up: 2011, Cartilage 2(3) 286–299
  • CS. Kasik, et al., Short-Term Outcomes for the Biologic Treatment of Bone Marrow Edema of the Knee Using Bone Marrow Aspirate Concentrate and Injectable Demineralized Bone Matrix; Arthroscopy, Sports Medicine, and Rehabilitation, Vol 1, No 1 (November), 2019: pp e7-e14

LipoPro Adipose-derived Cell Technology

  • Freitag et al., Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial, Regenerative Medicine 2019
  • Bellei, Migliano, et al., Maximizing non-enzymatic methods for harvesting adipose-derived stem from lipoaspirate: technical considerations and clinical implications for regenerative surgery, Scientific Reports. 2017, Vol 7., 10015

Procenta Allograft Tissue Matrix

ReVIVIFY Flowable Allograft Liquid

  • Nyman E., Huss F., Nyman T., Junker J., Kratz G. (2013 Apr), Hyaluronic acid, an important factor in the wound healing properties of amniotic fluid; in vitro studies of re-epithelialization in human skin wounds. J Plast Surg Hand Surg. 47(2):89-92
  • Adzick N.S., Lorenz H.P., (1994 Jul) Cells, matrix, growth factors, and the surgeon. The biology of scarless fetal wound repair. Annals of Surgery.; 220(1): 10-18
  • Gao X., Devoe L.D., Given K.S., (1994 Aug) Effects of amniotic fluid on proteases; a possible role of amniotic fluid in fetal wound healing. Annals of Plastic Surgery. 33(2): 128-134; discussion 134-135
  • Bolat F., Kocamaz F., Kulahcilar Z., Yilmaz A., Topcu A., Ozdemir M., Coskun M. (2013 Dec) Investigation of efficacy of mitomycin-C, sodium hyaluronate and human amniotic fluid in preventing epidural fibrosis and adhesion using a rat laminectomy model. Asian Spine J. 7(4): 253-9
  • Cobanglu U., Kutlu N., Karacal N., Kosucu P. (2005 Dec) Effect of human amniotic fluid on bone healing. J Surg Res. 129(2): 283-7
  • Ozgenel G., Filiz G., Ozcan M. (2004 Jul) Effects of amniotic fluid on cartilage regeneration from free perichondrial grafts in rabbits. Br J Plast Surg. 57(5): 423-8
  • Rosner M., Hipany K., Shanmugasundaram B., Lubec G., Hengstschlager M. (2012 Jun) Amniotic Fluid Stem Cells: Future Perspectives. Stem Cells Int. 2012: 741810

ARTHRODESIS / FUSION

Solutions

SpartanFuse100 DBM Putty & DBM Crunch

OsteoAmp Allogenic Morphogenic Proteins

SYNTHETIC OPTIONS